• to ail, to annoy, to chagrin, to discommode, to displease, to distress, to grieve, to injure, to jar, to maltreat, to offend, to outrage
• chagrin, distress, grief, heartache, rue, sorrow, tribulation, woe
• to handle, to manipulate, to use
• grating, hurtful, invidious, offending
• to prey on sy, to prey upon sy
• to deal by, to deal with, to entreat, to play, to treat
• to leave alone, to let alone
• I don't mind, I don't mind if I do, I'm easy